The former secretary of state and 2016 Democratic nominee will begin hosting an audio show to be released in late spring.
The podcast, which does not yet have a name, will be co-produced by iHeartMedia. Politico first reported news of Clinton's forthcoming podcast.
Even before the podcast is released, Clinton has shown a willingness throughout the Democratic primary to speak candidly about the crowded field and reflect on her general election loss in 2016.
In an interview with BBC Radio last November, Clinton said she thinks "all the time about what kind of president I would've been and what I would've done differently and what I think it would've meant to our country and the world."