US Vice President JD Vance is expected to arrive in Islamabad on Wednesday, sources close to the mediation have told Al Jazeera, Report informs.
He is expected to depart Washington, DC, on Tuesday evening Pakistan time, arriving in the Pakistani capital by late morning or early afternoon on Wednesday.
Vance is set to lead the US delegation for a second round of talks with Iran, with negotiations tentatively planned for Wednesday. Trump envoys Steve Witkoff and Jared Kushner are also expected to travel to Pakistan, maintaining the same level of delegation as the first round.
Several US military aircraft have already landed in Pakistan before the expected talks.
Whether Iran's delegation will arrive, however, remains uncertain. Iran's parliament speaker and head of its negotiating team, Mohammad Bagher Ghalibaf, said on Tuesday that Tehran "does not accept negotiations under the shadow of threats", casting doubt on whether a second round will take place as planned.