Scientists in Japan develop experimental tooth-growing drug

A team of scientists in Japan is hoping to make their tooth-growing drug a reality in the near future. Following recent promising research in animals, the group is planning to conduct small-scale human trials of the drug starting next year. Should everything go well, the treatment could reach the public by the end of the decade.

Report informs via foreign media that the experimental treatment is being developed by scientists at the Medical Research Institute Kitano Hospital in Osaka and other institutions. It’s a drug designed to block the action of a protein known as USAG-1. Years earlier, the team conducted research showing that mice lacking the gene needed to produce USAG-1 would go on to grow extra teeth. Their work found that USAG-1 seems to interact with other proteins to suppress tooth growth. And eventually, they appeared to find an antibody that would safely block one of these interactions while not having dangerous side effects elsewhere.

The drug will be tested in people with anodontia, a rare genetic condition that leaves them unable to grow any teeth. Should the clinical trial process pan out, Takahashi envisions that the drug could receive regulatory approval by 2030, initially as a treatment for children with anodontia between the ages of 2 to 6.