Khabib Nurmagomedov was due to headline UFC 253 against Justin Gaethje in September but has now pulled out of the fight following his father's death earlier this month.
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"Khabib will not take part in this tournament," Magomedov said.
Nurmagomedov's coach and father tragically passed away aged 58 due to complications suffered after contracting coronavirus.
The 31-year-old's last fight was on September 7, 2019, in which he defended his title in a duel with American Dustin Poirier.